Cellular senescence : searching for the philosopher ‘s stone
Scientific program
Zoe Draelos
Cosmeceuticals: what’s new in anti-aging?
Zoe Diana Draelos, MD, is a research and clinical board-certified dermatologist and a Fellow of the American Academy of Dermatology. She is in solo private practice in High Point, North Carolina, and an Adjunct Assistant Professor of Dermatology at Duke University. In 1988, she founded Dermatology Consulting Services, PLLC, to initiate and perform research in aging skin, acne, rosacea, psoriasis, atopic dermatitis, actinic keratoses, eczema, and aesthetic procedures in the cosmetic, OTC drug, and pharmaceutical areas. Prior to pursuing a medical career, Dr. Draelos completed an undergraduate degree in Mechanical Engineering and was elected a Rhodes Scholar. A member of Sigma Xi research honorary and Alpha Omega Alpha medical honorary, she is author of 14 books including Cosmetics in Dermatology and Hair Cosmetics. She is the editor of Cosmetic Dermatology: Products and Procedures and Cosmeceuticals, both in their third edition with translations into 7 languages. She has contributed chapters to 44 textbooks, written 120 posters, served as the principle investigator on 862 studies, written 612 published papers, delivered 360 oral presentations, served on or contributed to 38 journal editorial boards, functioned as the editor-in-chief of the Journal of Cosmetic Dermatology for 10 years, and was a past member of the Board of Directors of the American Academy of Dermatology and the American Society for Dermatologic Surgery. She was elected Vice-President of the American Academy of Dermatology. She is recognized as a pioneer in cosmetic dermatology and received a lifetime achievement award from Health Beauty America for her research and the 2008 DermArts award for her contributions to dermatology. In 2010, she received the Albert Kligman Innovation Award and in 2016 she was awarded a Presidential Citation from the American Academy of Dermatology for her research contributions to advance the specialty. She received the prestigious Maison deNavarre award from the Society of Cosmetic Chemists for her contributions to the art and science of cosmetics in 2017. In 2019, she was the inaugural recipient of the Florence Wall Award from the Society of Cosmetics Chemists honoring her as the most influential woman in cosmetic science.
Jean-Marc Lemaitre
Emerging approaches to target the hallmarks of aging in the skin
Jean-Marc Lemaitre is Co-Director of the Institute of Regenerative Medicine and Biotherapies of Montpellier (France) since 2015. He started his career in 1984 as engineer at CNRS (National Center for Scientific Research). After a Ph.D. of Molecular and Cellular Biology of Development at Paris 7 University received in 1995 and a Post-Doc at Jacques Monod Institute in Paris, he joined the Institute of Human Genetics of Montpellier (IGH), where he obtained a tenure position at INSERM (National Institute for Scientific and Medical Research) in 2004.
As major achievements, he demonstrated the existence of an overlap between mitosis and S phase in rapid cell of early embryogenesis (Lemaitre et al., JCB 1998), he identified CDC6 the only oocyte missing replicating factor translated during maturation to give the competence to replicate to the embryo (Lemaitre et al., Nature 2002) and identified mitosis as a key step in the reprogramming of the genome in nuclear transfer experiments (Lemaitre et al., Cell 2005). Awarded by an AVENIR INSERM Program in 2006, he obtained a senior Group leader position in 2010 at the Institute of Functional Genomics of Montpellier (IGF) working on Genome and Stem Cell Plasticity in aging. He mapped replication origins in human cells and identified a G-quadruplexes as a consensus sequence for priming (Besnard et al., NSMB 2012) and identified replication timing domain signatures of physiological and accelerated aging (Riveria-Mulla et al., PNAS 2017). He identified DNMT1 as a major actor in the reorganization of chromosomes in SAHFs during senescence induced by oncogene (Sati et al., Mol Cell 2020).
His main contributions include the demonstration of cellular aging reversibility through a patented iPSC reprogramming strategy, as a new paradigm of cell rejuvenation (Lapasset et al., Genes &Dev 2011) and that a single in vivo transient reprogramming might prevent age related diseases (Alle et al., Aging Cell 2022).
He is co-founder and advisor of two startup INGRAALYS (dedicated to skin rejuvenation and hair regrowth by reprogramming strategies) and ORGANIPS (dedicated to the production of human organoids from iPSC).
Ediléia Bagatin
Current approach and perspectives in skin aging control: contribution from Latin America
Ediléia Bagatin is Associate professor at Department of dermatology (EPM/UNIFESP), Sao Paulo, Brazil.
After graduating in medicine (1974-1979), Pontifical Catholic University of Sao Paulo(PUC-SP), she pursued a master (1985) and PhD degrees (1994) in the Department of Dermatology, Paulista School of Medicine, at the Federal University of Sao Paulo (EPM/UNIFESP). Scientific Initiation (since 2006); Research lines: oral isotretinoin; skin aging; acne; healing, trichology; pigmented lesions; dermocosmetics. Prof.Bagatin is board member and vice-coordinator of the Research Ethics Committee (UNIFESP), board member of the Research Ethics Committee at the Faculty of Pharmaceutical Science (USP), member of Scientific Committee and coordinator of Cosmetic Dermatology Department of the Brazilian Society of Dermatology. She is member of Skin Group for Evidence Based Guidelines and Cochrane Systematic Reviews and Cochrane Collaboration, Governing board, and member of Technical Group for Cosmetics of Brazilian Healthy Regulatory Agency - ANVISA, and member of Editorial Board of the International Society of Dermatology.
Participation in numerous national and international annual Congresses and Courses on Dermatology and Clinical Research.
Ingrid López Gehrke
Multilevel combined therapy: from the epidermis to the deep tissue
Dra. Ingrid López-Gehrke
Dermato-oncologist and skin cancer specialist
Medical Director at Haut Klinik Dermatological Clinic in Mexico City.
Key opinion leader. Graduated with honors as a Surgeon from the University of Veracruz in Mexico; with a specialty in Dermatology from the General Hospital of Mexico, subspecialist in Dermato-oncology and Skin Cancer from the National Autonomous University of Mexico, she’s currently the medical director of Haut Klinik Private Dermatology Clinic in Mexico City. Also to being a national and international invited professor as an expert in various fields of oncological dermatology, onychopathies and cosmetic dermatology with a special focus on global rejuvenation techniques with hyaluronic acid, botulinum toxin, polycaprolactone, resorbable support sutures, calcium hydroxyapatite, polylactic acid, enzyme therapies among other specialized medical procedures. She's affiliated at various dermatology groups, being in all these visiting professor and active member to date. She’s a full member of the Mexican Academy of Dermatology, Spokesperson for the Mexican Foundation of Dermatology where she participated as Pro-Secretary in the 2014-2015 biennium. Full member of the Mexican Society of Dermatology, the Mexican Society of Dermatological and Oncological Surgery, the Mexican Association of Medical Mycology and the Ibero-Latin American College of Dermatology. Author and co-author of various publications in medical-scientific journals of national and international impact, Co-author and author of several chapters in specialized medical books and reviewer for various works in Mexican Dermatologic Magazine from 2016 to date. In 2019 she founded Haut Group which is conformed by Haut Klinik Dermatologic Clinic, Haut Boutique Dermatologic Pharmacy, Haut Wellness Lifestyle Medicine, and Haut Akademie Cosmetic Dermatology Science.
Jean-Hilaire Saurat
Targets and weapons in skin aging: concepts and proofs
Jean-Hilaire Saurat, MD,is professor emeritus at Geneva University where he chaired the department of Dermatology for 28 years. He had studied Dermatology at the Hôpital Saint-Louis, and Experimental Pathology at the Faculté Necker Enfants Malades, both in Paris.
Prof. Saurat has been President of the International League of Dermatological Societies (ILDS), President of the European Society for Dermatological Research (ESDR), and the European Academy of Dermatology and Venereology (EADV). Prof. Saurat has been chief editor of Dermatology 1986-2015 , and has been section editor of the Journal of Investigative Dermatology 1987-1997. He is the leading editor for editions 1st through 6th of the French Textbook of Dermatology Elsevier-Masson pub. Prof. Saurat’ current research includes: sebaceous glands pathophysiology, skin aging/dermatoporosis, dermatotoxicology, and retinoids. His past research interests have included inflammatory skin diseases, graft-versus-host reaction, severe drug reactions, and pediatric dermatology. Prof Saurat currently has a selected private practice in Geneva.
Prof. Saurat citations report indicates his 1.027 publications were cited 24.845 times, with an h-index of 75.
Prof. Saurat is “Chevalier de la Légion d’Honneur” France.
Patrick Bogdanowicz
Actives to target skin cells senescence
Patrick Bogdanowicz is a researcher in Skin Pharmacology at the Pharmaco-Clinical Research Department of Pierre Fabre Dermo-cosmetique
He has a PhD “Cellular and Molecular Biology” and MSc “Biochemistry and Applied Biology” with 13 years of academic research at University of Caen (France) and Toronto (Canada).Then he was assistant & assistant lecturers for 2 years at the University of Caen (France).
Laureate of the French Academy of Medicine, he’s currently researcher for 16 years in Pharmacology at Pierre Fabre Laboratories (Toulouse, France).
Its areas of expertise are Skin Aging, Skin Pigmentation and Hair Physiopathology from cell to human skin
He is in charge of evaluation of active ingredients and dermo-cosmetic formulations (anti-aging and skin pigmentation), and has expertise in biomimicry.
He works on the development of innovative 2D and 3D skin models and biological target screening on multi-Omics technologies (proteomic, transcriptomic…), and sets up pharmaco-clinical trials in healthy volunteers and skin care product testing.
He has french and international collaborations in dermo-cosmetic research and is author of 24 papers in peer reviews journal and co-inventor of 7 patents.
